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class="e_text-131 s_title"> 鏃ユ湡锛 </p><P class="e_timeFormat-127 s_title">2025骞?4鏈?4鏃 16:33</P></div> </div><hr class="e_line-132 s_line" /><div class="e_richText-133 s_title clearfix" aid="" tid="" cid="" code="datasource4.current.richtext_n2J31RC5" > <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">浠ｈ阿鐤剧梾鏄満浣撲唬璋㈣繃绋嬪紓甯歌€屽紩鍙戠殑涓€绯诲垪鐤剧梾锛屼富瑕佹槸浣撳唴鐗╄川锛堝纰虫按鍖栧悎鐗┿€佽剛鑲€佽泲鐧借川绛夛級鐨勫悎鎴愩€佸垎瑙ｆ垨鎺掓硠杩囩▼鍙戠敓闅滅锛屽鑷磋兘閲忓埄鐢ㄦ垨钀ュ吇鐗╄川浠ｈ阿绱婁贡銆傝繖绫荤柧鐥呭彲鑳界敱閬椾紶銆佺幆澧冦€佺敓娲绘柟寮忕瓑鍥犵礌寮曡捣锛岃〃鐜颁负浠ｈ阿鐗╃Н绱垨缂轰箯锛屼粠鑰屽紩鍙戜竴绯诲垪涓村簥鐥囩姸鍜屽仴搴烽棶棰樸€備唬璋㈢柧鐥呭寘鎷绉嶇被鍨嬶紝濡傜硸灏跨梾锛堣绯栨按骞冲崌楂橈級銆佽偉鑳栫棁锛堜笌鑴傝偑浠ｈ阿绱婁贡鐩稿叧锛夈€侀珮鑴傝鐥囷紙涓庤剛璐ㄤ唬璋㈠紓甯告湁鍏筹級銆佺棝椋庯紙灏块吀浠ｈ阿寮傚父锛変互鍙婁唬璋㈢患鍚堝緛锛堝寘鎷珮琛€鍘嬨€侀珮琛€绯栥€侀珮琛€鑴傚拰鑲ヨ儢绛夛級銆傚叾涓紝鑲ヨ儢鐥囨槸涓€绉嶅鏉傜殑澶氬洜绱犵柧鐥咃紝閫氬父涓庨仐浼犲拰鐜鍥犵礌鏈夊叧锛屽彂杈惧浗瀹跺拰鍙戝睍涓浗瀹剁殑鑲ヨ儢鎮ｇ梾鐜囧拰姝讳骸鐜囬€愬勾鏄捐憲澧炲姞锛屾槸涓栫晫鑼冨洿鍐呯殑涓昏鍋ュ悍闂涔嬩竴銆侟/span></span></p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">鍦ㄥ綋浠婂叏鐞冭偉鑳栫棁楂樺彂鐨勪弗宄诲舰鍔夸笅锛屼竾閭﹀痉鍒惰嵂闆嗗洟鏈夐檺鍏徃甯冨眬浜嗛拡瀵归粦鐨川绱犲彈浣擄紙MCR锛夌殑灏忓垎瀛愭柊鍨嬬幆鑲界郴鍒楁柊鑽紝甯屾湜鍦ㄤ唬璋㈤鍩熻础鐚樊寮傚寲鐤楁硶銆傛棩鍓嶏紝鍏徃鍏ㄦ柊鍊欓€夊寲鍚堢墿鍙栧緱浜嗙Н鏋佺殑涓村簥鍓嶆暟鎹紝鍦ㄨ偉鑳栧皬榧犳ā鍨嬩笂锛岃瀵熷埌“闄嶈偉鑲夈€佷繚鑲岃倝”鐨勯鏈熸晥鏋溿€侟/span></span></p> <p style="text-indent: 2em; text-align: justify;"> </p> <p style="text-indent: 2em; text-align: justify;"> </p> <p style="text-indent:2em;"><img id="1207" src="https://omo-oss-image.thefastimg.com/portal-saas/pg2025090508412671444/cms/image/055916ce-faef-45b0-8d0b-6d8472e90354.jpg" style="width: 600px; height: 600px; float: none; display: block; margin-left: auto; margin-right: auto; text-align: justify;" /></p> <p style="text-indent: 2em; text-align: center;"><strong>鑲ヨ儢鐩稿叧鐨勫仴搴烽闄╁拰骞跺彂鐥嘃/strong></p> <p style="text-align: justify;"> </p> <p style="text-align: center;"><strong><span style="font-size:18px;"><span style="line-height:2;">浣滅敤鏈哄埗</span></span></strong></p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">MCR鏂板瀷鐜偨鐨勪唬璋㈣皟鑺備綔鐢ㄦ簮浜庡榛戠毊璐ㄧ礌-4鍙椾綋锛圡C4R锛夌殑婵€娲汇€侻C4R浣滀负鑳介噺绋虫€佺殑“涓灑鎸囨尌瀹?rdquo;锛岄€氳繃澶氱淮搴﹁皟鎺х綉缁滄潵鎶戝埗杩囧害鎽勯銆佽皟鑺傝憽钀勭硸鍜岃剛璐ㄦ按骞炽€佺淮鎸佽倢鑲夌ǔ鎬侊紝浠庤€屽疄鐜扮患鍚堜唬璋笌鑳介噺骞宠　銆侟/span></span></p> <p style="text-indent: 2em; text-align: justify;"> </p> <p style="text-indent: 2em; text-align: justify;"> </p> <p style="text-indent:2em;"><img id="1208" src="https://omo-oss-image.thefastimg.com/portal-saas/pg2025090508412671444/cms/image/1708ad49-7601-41df-8290-dc2035377e2c.jpg" style="width: 600px; height: 411px; float: none; display: block; margin-left: auto; margin-right: auto; text-align: justify;" /></p> <p style="text-indent: 2em; text-align: center;"><strong>榛戣壊鐨川绱犱粙瀵肩殑鑳介噺骞宠　璋冩帶鏈哄埗</strong></p> <p style="text-indent: 2em; text-align: justify;"> </p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">α - 淇冮粦绱犵粏鑳炴縺绱狅紙α-MSH锛夊榛戠毊璐ㄧ礌鍙椾綋4锛圡C4R锛夌殑婵€娲讳細瀵艰嚧G铔嬬櫧锛圙αs锛夋椿鍖栵紝闅忓悗鑵鸿嫹閰哥幆鍖栭叾锛圓C锛夎婵€娲伙紝AC灏嗕笁纾烽吀鑵鸿嫹锛圓TP锛夎浆鍖栦负鐜７鑵鸿嫹閰革紙cAMP锛夈€傜幆纾疯吅鑻烽吀锛坈AMP锛変粙瀵肩殑铔嬬櫧婵€閰禔锛圥KA锛夌殑娲诲寲浼氬鑷碢KA澶嶅悎鐗╁偓鍖栦簹鍩虹殑瑙ｇ銆傚綋鏈夋椿鎬х殑PKA鍌寲浜氬熀锛圥KA*锛夎浆绉昏嚦缁嗚優鏍稿悗锛孭KA浣胯浆褰曞洜瀛愮幆纾疯吅鑻烽吀鍙嶅簲鍏冧欢缁撳悎铔嬬櫧锛圕REB锛夌７閰稿寲銆傚綋鐜７鑵鸿嫹閰稿弽搴斿厓浠剁粨鍚堣泲鐧 - 纾烽吀鍖栵紙CREB-P锛変笌涓婃父涓€鑷存€NA搴忓垪锛堢幆纾疯吅鑻烽吀鍙嶅簲鍏冧欢锛孋RE锛夌粨鍚堟椂锛屽畠閫氳繃涓庢牳蹇冭浆褰曟満鍒剁浉浜掍綔鐢ㄦ潵淇冭繘浠ｈ阿涓庤兘閲忓钩琛¤皟鑺傜浉鍏冲熀鍥犺浆褰曘€侟/span></span></p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">AC锛氳吅鑻烽吀鐜寲閰讹紱AgRP锛氬埡榧犵浉鍏宠泲鐧斤紱α - MSH锛?alpha; - 淇冮粦绱犵粏鑳炴縺绱狅紱CREB锛氱幆纾疯吅鑻烽吀鍙嶅簲鍏冧欢缁撳悎铔嬬櫧锛汫LP-1锛氳儼楂樿绯栫礌鏍疯偨-1锛汳C4R锛氶粦鐨川绱犲彈浣?锛汵PY锛氱缁忚偨锛汸KA锛氳泲鐧芥縺閰禔锛汸OMC锛氶樋榛戠毊绱犲師銆侟/span></span></p> <p style="text-indent: 2em; text-align: justify;"> </p> <section> <section> <section> <p style="text-align: center;"><span style="font-size:18px;"><span style="line-height:2;"><strong>涓村簥鍓嶅疄楠岋細</strong><strong>MCR鏂板瀷鐜偨瀵逛綋閲嶃€佷綋鑴傘€佽倢鑲夌殑褰卞搷</strong></span></span></p> <section> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">涓轰簡鍏ㄩ潰璇勪及 MCR鏂板瀷鐜偨鐨勭枟鏁堬紝鎴戜滑閫夊彇浜嗙洰鍓嶄唬璋㈤鍩熷箍娉涘簲鐢ㄧ殑 GLP-1 鍙椾綋婵€鍔ㄥ墏鍙哥編鏍奸瞾鑲戒綔涓洪槼鎬у鐓э紝鍦ㄩ泟鎬57灏忛紶涓婏紝閲囩敤楗璇卞鑲ヨ儢锛圖IO锛夋ā鍨嬶紝妯℃嫙浜虹被鑲ヨ儢鐥囩殑鍙戠敓鍙戝睍杩囩▼锛屽湪鎸佺画7鍛ㄧ殑缁欒嵂杩囩▼涓紝鍏ㄧ▼缁欎簣楂樿剛楗銆傝瘯楠岃缃簡闃存€у鐓х粍锛堢┖鐧芥憾鍓傦級銆侀槼鎬у鐓х粍锛堢粰浜堝徃缇庢牸椴佽偨锛夈€丮CR鏂板瀷鐜偨浣庛€侀珮鍓傞噺缁勶紝浠ュ強MCR鏂板瀷鐜偨涓庡徃缇庢牸椴佽偨鑱旂敤缁勩€傞€氳繃瀵规瘮涓嶅悓缁勯棿鐨勪綋閲嶅彉鍖栥€佽剛鑲彉鍖栥€佽倢鑲夊彉鍖栫瓑鎸囨爣锛岃瘎浠疯嵂鏁堝鐗规€с€侟/span></span></p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">瀹為獙缁撴灉鏄剧ず锛屽湪杩涢楂樿剛楗鏈熼棿锛屼笌绌虹櫧婧跺墏缁勭浉姣旓細</span></span></p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">1銆?/span></span><span style="font-size:16px;"><span style="line-height:2;">鍚勭粰鑽粍鍧囪瀵熷埌涓嶅悓绋嬪害鐨勪綋閲嶉檷浣庯紱</span></span></p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">2銆?/span></span><span style="font-size:16px;"><span style="line-height:2;">鍗曠嫭鐢ㄥ徃缇庢牸椴佽偨娌荤枟锛岃剛鑲殑缁濆璐ㄩ噺銆佽剛鑲?浣撻噸鐧惧垎姣旓紙%锛夊潎鏄捐憲闄嶄綆锛岃倢鑲夌粷瀵硅川閲忔湁鎵€鍑忓皯锛堝疄楠屾湯鏈熻緝鍩哄€煎噺灏戠害8%锛夛紱</span></span></p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">3銆?/span></span><span style="font-size:16px;"><span style="line-height:2;">鍗曠嫭鐢∕CR鏂板瀷鐜偨娌荤枟锛堥珮鍓傞噺缁勶級锛岃剛鑲殑缁濆璐ㄩ噺銆佽剛鑲?浣撻噸鐧惧垎姣旓紙%锛夊潎鏄捐憲闄嶄綆(闄嶄綆骞呭害浣庝簬鍙哥編鏍奸瞾鑲斤級锛岃倢鑲夌粷瀵硅川閲忔湁鎵€澧炲姞锛堝疄楠屾湯鏈熻緝鍩哄€煎鍔犵害4%锛夛紱</span></span></p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">4銆?/span></span><span style="font-size:16px;"><span style="line-height:2;">鑱斿悎浣跨敤鍙哥編鏍奸瞾鑲?MCR鏂板瀷鐜偨鏃讹紝鍑忚剛绋嬪害涓庡崟鐢ㄥ徃缇庢牸椴佽偨鎺ヨ繎锛岃倢鑲夌粷瀵硅川閲忓噺灏戞儏褰㈡瘮鍗曠敤鍙哥編鏍奸瞾鑲芥湁鎵€鏀瑰杽锛堝疄楠屾湯鏈熻倢鑲夎緝鍩哄€煎噺灏戠巼澶х害4%锛夛紱</span></span></p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">5銆?/span></span><span style="font-size:16px;"><span style="line-height:2;">鍚勭粍浜﹀湪琛€绯栥€佽鑴傚悇椤规寚鏍囪瀵熷埌绉瀬鏁堟灉銆侟/span></span></p> <p style="text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;"><strong>瀹為獙缁撴灉瑙ｈ锛欬/strong></span></span></p> <p style="text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;"> 浠庢暟鎹潵鐪嬶紝鍏徃鏂板紑鍙戠殑MCR鏂板瀷鐜偨鍦ㄥ噺灏戣剛鑲殑鍚屾椂锛屽疄鐜颁簡淇濊倢銆佸鑲岀殑鏁堟灉銆備笌鍙哥編鏍奸瞾鑲借仈鐢ㄦ椂锛屼害鏀瑰杽鍏跺鑲岃倝娴佸け鐨勫奖鍝嶃€侟/span></span></p> <p style="text-indent:2em;"><span style="font-size:16px;"><span style="line-height:2;">MCR鏂板瀷鐜偨宸紓鎬х殑鑽悊浣滅敤鏈哄埗锛屼娇鍏跺湪闄嶄綆浣撻噸銆佸噺灏戣剛鑲殑鍚屾椂锛岃緝濂藉湴鏀瑰杽韬綋鐨勮倢鑲夎川閲忥紝甯︽潵瀵规暣浣撲唬璋㈡儏鍐电殑绉瀬褰卞搷銆侟/span></span></p> <p style="text-indent:2em;"> </p> <p style="text-align: justify;"><img id="1206" src="https://omo-oss-image.thefastimg.com/portal-saas/pg2025090508412671444/cms/image/c40a02f2-1fa4-4f31-aff3-9193fc042b72.jpg" style="width: 600px; height: 205px; float: none; display: block; margin-left: auto; margin-right: auto;" /></p> <p style="text-align: center;"><strong>G1绌虹櫧婧跺墏缁刓G2鍙哥編鏍奸瞾鑲界粍\G3MCR鏂板瀷鐜偨缁凕/strong></p> </section> <section> <section> <section> <p style="text-align: justify;"> </p> <p style="text-align: center;"><span style="font-size:18px;"><span style="line-height:2;"><strong>鎰忎箟锛氫粠瀹為獙瀹ゅ埌涓村簥鐨勫垱鏂版帹杩汓/strong></span></span></p> </section> </section> <section> <section> <section> <section> <section> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">涓囬偊寰峰埗鑽泦鍥㈠湪澶氳偨鍒涙柊鑽爺鍙戦鍩熷彇寰楃Н鏋佹暟鎹€傚€煎緱涓€鎻愮殑鏄紝椤圭洰浠庨澏鐐圭瓫閫夊埌鍒嗗瓙浼樺寲涓哄畬鍏ㄨ嚜涓荤爺鍙戯紝鎷ユ湁100%鑷富鐭ヨ瘑浜ф潈銆傞」鐩嵆灏嗘鍏ユ敮鎸佷复搴奍ND鐢虫姤鐨勭爺绌堕樁娈碉紝鏀寔澶氳偨鏂拌嵂鍚庣画鐨勪复搴婂紑鍙戙€侟/span></span></p> <p style="text-indent: 2em; text-align: justify;"><span style="font-size:16px;"><span style="line-height:2;">浠庝复搴婂簲鐢ㄧ殑瑙掑害鏉ョ湅锛孧CR鏂板瀷鐜偨鏈夋湜涓鸿秴閲嶃€佷唬璋㈠け琛＄瓑浜虹兢甯︽潵涓嶅悓鐨勪复搴婇€夋嫨锛屽湪璋冭妭浣撻噸銆佸噺灏戣剛鑲殑鍚屾椂锛岄伩鍏嶈倢鑲夎川閲忔祦澶辨垨淇冭繘鑲岃倝澧炲姞锛屾敼鍠勬偅鑰呯殑浠ｈ阿鐘跺喌锛岄檷浣庣浉鍏冲苟鍙戠棁鐨勫彂鐢熼闄┿€侟/span></span></p> <p style="text-indent: 2em; text-align: justify;"> </p> </section> </section> </section> 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